王慧

王慧，博士，副教授，硕士生导师(药物化学方向)，皖南医学院学术和技术带头人后备人选，化学教研室秘书。以第一/通讯作者在Biosensors and Bioelectronics、Sensor. Actuat. B-Chem等学术期刊发表SCI论文30余篇，授权国家发明专利5项，先后主持安徽省自然科学项目、安徽省高校科研项目、教育厅人才项目、校青年骨干人才项目及校中青年科研项目，参编教材1部。2022年获“优秀教师”荣誉称号，2020-2021学年和2018-2019学年分别获“优秀班主任”荣誉称号。指导学生获第十三届全国大学生“药苑论坛”创新成果一等奖、第十一届芜湖市“大学生专利创新大赛”特等奖、第十届安徽省挑战杯二等奖等各类国家/省级/市级/校级奖项共计20余项。指导本科生以第一作者发表科研论文20余篇。

【主要研究方向】荧光探针及生物成像

【联系方式】wanghias@126.com,0553-3932472

【教育学习经历】

2007.09-2011.06       安徽大学       材料化学              本科

2011.09-2017.06       安徽大学       无机化学(硕博连读)     博士   

【主要科研项目】

1. 安徽省高校科研项目重点项目2023AH051762靶向内质网的近红外极性荧光探针的构筑及其在非酒精性脂肪肝病中的应用研究2023.8-2025.7 主持，在研

2. 安徽省自然科学基金青年项目 1908085QB50含Ir-C键功能化配合物的组氨酸荧光探针的构筑及其生物学应用研究 2019.7-2021.6 主持，结题

3. 高校优秀青年骨干教师国内访学项目 gxgnfx2021124 2021.1-2023.12 主持，在研

4. 皖南医学院青年骨干人才项目 2021.1-2023.12  主持，在研

【近五年代表性论文】

1. Hui Wang, Cuifeng Zhang, Xuebin Shen, Zhiyu Wang, Jing Yang, Shuting Shen, Lei Hu, Jin Pan, Xiaoxia Gu.Rational design AIE fluorescent probes for wash-free and lipid droplet specific imaging of fatty liver based on coumarin. Dyes and Pigments, 2023, 212: 111137.

2. Jing Yang, Zhiyu Wang, Jiayi Ge, Yi Deng, Feiyang Ding, Lei Hu*, Hui Wang*. A deep-red emission AIE fluorescent probes based on coumarin for imaging lipid droplets in living cells. Journal of Molecular Structure, 2023, 1277: 134847.

3. Lei Hu, Jin Pan, Cuifeng Zhang, Kun Yu, Shuting Shen, Yaxuan Wang, Xuebin Shen, Xiaoxia Gu, Jun Han*, Hui Wang*. Polarity-sensitive and lipid droplet-specific red emission fluorophore for identifying fatty liver of living mice through in vivo imaging. Biosensors and Bioelectronics, 2022, 216: 114618.

4. Lei Hu, Bingsong Xu, Hao Chen, Hui Wang*. A water-soluble AIEgen for ultrafast and wash-free imaging of plasma membranes in biosystems. Sensors & Actuators: B. Chemical, 2021, 340: 129950.

5. Hui Wang*, Lei Hu, Shuting Shen, et al. A polarity-sensitive fluorescent probe based on a difluoroboron derivative for monitoring the variation of lipid droplets. New Journal of Chemistry, 2021, 45: 21553-21556.

6. Lei Hu, Xi Chen, Kun Yu, Na Huang, Hailing Du, Yan Wei, Yunjun Wu, Hui Wang*. Weak-emission iridium(III) complexes as fluorescent turn-on probes for ultrasensitive and selective imaging histidine in living cells and rat tissues. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 262: 120095.

7. Hui Wang, Lei Hu, Bingsong Xu, et al. Endoplasmic reticulum-targeted fluorogenic probe based on pyrimidine derivative for visualizing exogenous/endogenous H₂S in living cells. Dyes and Pigments, 2020, 179, 108390.

8. Hui Wang, Fengze Cai, Le Zhou,et al. A red-emissive mitochondrial probe for imaging of the viscosity in living cells. New Journal of Chemistry, 2019, 43, 8811-8815.

9. Hui Wang, Lei Hu, Wei Du, et al. Mitochondria-targeted iridium (III) complexes as two-photonfluorogenic probes of cysteine/homocysteine. Sensors & Actuators: B. Chemical, 2018, 255, 408-415.